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Watch An Oprah Winfrey Special Season 2025 Episode 1 online — it may be available on legal streaming platforms such as YouTube, Netflix, Prime Video, Hulu, Disney+, and others.

As women strive to understand and openly discuss the changes that impact every cell of their bodies, and new research shows women as young as 35 starting to show symptoms of perimenopause, Winfrey brings together a panel of renowned medical experts and leading voices to discuss the traditionally taboo topic of menopause before a live studio audience. Featured will be a group of women from all walks of life who have experienced a wide array of midlife transitions, as well as experts who explore the physical and neurological changes that occur during this life stage — a change that impacts every woman.