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Watch The Drew Barrymore Show Season 4 Episode 49 online — it may be available on legal streaming platforms such as YouTube, Netflix, Prime Video, Hulu, Disney+, and others.

Drew is spending the entire show celebrating the release of "Mean Girls" with the cast including stars Reneé Raap, Angourie Rice, Avantika, Bebe Wood, Christopher Briney, Auli'I Cravalho and Jaquel Spivey. The "Mean Girls" takeover continues with the entire cast of the movie playing a round of a trust fall game.